ScenTree, la nouvelle encyclopédie des ingrédients de parfum.

Exploring the branches of scent

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Crédits photo: ScenTree SAS

CAS number :

469-61-4

EINECS number :

207-418-4

FEMA number :

Data not available.

JECFA number :

Data not available.

FLAVIS number :

01.022

Volatility :

Base

Appearance :

Colorless liquid

Price Range :

€€

Stability :

Terpenes tend to polymerize by oxydation

Density :

0.93

Molecular formula :

C₁₅H₂₄

Molecular Weight :

204.35 g/mol

Flash Point :

219.2°F (104°C)

Log P :

Data not available.

Fusion Point :

Data not available.

Boiling Point :

503.6°F (262°C)

Detection Threshold :

Data not available.

Crédits photo: ScenTree SAS

Year of discovery :

Isolated by scientist Walter in 1841 (ex. Juniperus virginiana). In 1953, Stork and Breslow were the first to synthesize dl-cedrol and dl-Alpha-Cedrene. Two years later, they acheived in synthesizing completely cedrol and Alpha-Cedrene.

Synthesis route :

There are several routes of synthesis for Alpha-Cedrene depending on the starting reagent. Only one of them is detailed below: One of the syntheses with the least steps is a Corey synthesis from 2-methylhept-2-enen lithiated in its carbon 6, reacting with 3-methoxycyclopent-2-enone. The obtained intermediate product undergoes a reduction with sodium borohydride, then a treatment with diiodomethane, catalysed by brass, and a pyrogenation in the presence of chromium trioxide and dichloromethane. An acetylation of the ketone function that is still present, allows to form a carbocation which, by rearrangement, forms epi-Alpha-Cedrene and Alpha-Cedrene.

Synthesis precursor :

Alpha-Cedrene is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

Alpha-Cedrene has several isomers, by delocalization of its double bond. We distinguish beta-Cedrene, which has a smell relatively similar to Alpha-Cedrene. Moreover, this molecule is a constitutional isomer of beta-Caryophyllene and Valencene, but has a smell much less spicy or green than these two isomers.

Natural availability :

Alpha-Cedrene is one of the major components of Cedarwood Virginia EO, Cedarwood Texas EO, Cedarwood Chinese EO, among others, and is present in trace amounts especially in Verbena EO.

Allergens :

This ingredient does not contain any allergen.

For more information on allergens used in perfumery, please consult our article about allergens

IFRA :

This ingredient is not restricted

Annexe I :

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration
Estragole	140-67-0	1
Eugenol	97-53-0	58
Methyl eugenol	93-15-2	2
Eugenol	97-53-0	85,3
Eugenol	97-53-0	0,2
Methyl eugenol	93-15-2	1,2
Geraniol	106-24-1	1,6
Citral	5392-40-5	0,5
Geraniol	106-24-1	1
Citral	5392-40-5	2
Geraniol	106-24-1	0,5
Geraniol	106-24-1	0,1
Methyl eugenol	93-15-2	1

Restriction type :

RESTRICTION QRA

Cause of restriction :

DERMAL SENSITIZATION

Amendment :

48

Comments :

Quantitative usage limits :

Cat.1	Cat.2	Cat.3	Cat.4	Cat.5	Cat.6	Cat.7	Cat.8	Cat.9	Cat.10	Cat.11
0,07 %	0,08 %	0,35 %	1,04 %	0,55 %	1,67 %	0,17 %	2 %	5 %	2,5 %	Not restricted

Skin contact products		Non skin contact products
Leave on products	Rinse off products	Non skin contact products
	0,001 %	0,01 %

Annexe I :

Some regulated synthetic ingredients are found in nature and in certain proportions in natural ingredients. This presence in nature has to be taken into account when calculating limits of use recommended by the IFRA. In case you do not know these concentrations, you can use the ones estimated by the IFRA. Here They are :

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration
Balsam oil, Peru	Myroxylon balsamum (L.) Harms var. pereirae (Royle) Harms	8007-00-9	0,03
Cinnamon bark extract	Cinnamomum spp.	8015-91-6	0,01
Cinnamon bark oil	Cinnamomum spp.	8015-91-6	0,02
Cinnamon leaf oil	Cinnamomum zeylanicum Blume	8015-91-6	0,13
Tolu, balsam, extract	Myroxylon balsamum (L.) Harms.	8024-03-1	0,08
Tolu, balsam, gum	Myroxylon balsamum (L.) Harms.	8024-03-1	0,02
Tuberose absolute	Poliantes tuberosa L.	8024-05-3	0,5
Tuberose concrete	Poliantes tuberosa L.	8024-05-3	0,5
Ylang ylang oil I	Cananga odorata (Lam.) Hook.f. & Thomson	8006-81-3	0,5
Ylang ylang oil II	Cananga odorata (Lam.) Hook.f. & Thomson	8006-81-3	0,5
Ylang ylang oil III	Cananga odorata (Lam.) Hook.f. & Thomson	8006-81-3	0,5
Ylang, Ylang oil extra	Cananga odorata (Lam.) Hook.f. & Thomson	8006-81-3	0,5
Ylang, Ylang oil, terpene-free	Cananga odorata (Lam.) Hook.f. & Thomson	68952-44-3	0,5
Allspice oil	Pimenta officinalis Lindl.	8006-77-7	5
Allspice oleoresin	Pimenta officinalis Lindl.	8006-77-7	3
Artemisia annua extract	Artemisia annua L.	84775-74-6	0,07
Basil oil, chemotype estragole	Ocimum basilicum L.	8015-73-4	0,5
Basil oil, chemotype linalool	Ocimum basilicum L.	8015-73-4	0,5
Basil oleoresin, chemotype estragole	Ocimum basilicum L.	84775-71-3	0,2
Bay leaves, West Indian, extract	Pimenta racemosa (Mill.) J.W. Moore	8006-78-8	1,4
Bay leaves, West Indian, oil	Pimenta racemosa (Mill.) J.W. Moore	8006-78-8	2
Bay oil, terpeneless	Pimenta racemosa (P. Mill.) J.W. Moore	68916-05-2	2,4
Calamus oil	Acorus calamus L.	8015-79-0	0,3
Cananga oil	Cananga odorata (Lam.) Hook.f. & Thomson	68606-83-7	0,2
Cinnamon leaf oil	Cinnamomum zeylanicum Blume	8015-91-6	0,01
Elemi gum	Canarium luzonicum (Blume) A. Gray	8023-89-0	0,07
Elemi oil	Canarium spp.	8023-89-0	0,2
Elemi resinoid	Canarium spp.	8023-89-0	0,07
Hyacinth absolute	Hyacinthus orientalis L.	8023-94-7	1,5
Hyssop oil	Hyssopus officinalis L.	8006-83-5	0,12
Laurel leaf oil	Laurus nobilis L	8007-48-5	9,4
Mace oil	Myristica fragrans Houtt.	8007-12-3	1,2
Mastic absolute	Pistacia lentiscus L.	61789-92-2	0,01
Mastic oil	Pistacia lentiscus L.	68991-39-9	0,02
Michelia alba extract	Michelia x alba DC. (champaca x montana)	92457-18-6	2,8
Myrtle oil	Myrtus communis L.	8008-46-6	1
Nutmeg oil	Myristica fragrans Houtt.	8008-45-5	1,2
Pimenta leaf oil	Pimenta officinalis Lindl.	8006-77-7	2
Rose absolute	Rosa x damascena Mill.	90106-38-0	0,5
Rose concrete	Rosa x damascena Mill.	90106-38-0	0,5
Rose oil	Rosa x damascena Mill.	8007-01-0	2
Snakeroot oil	Asarum canadense L.	8016-69-1	40
Tarragon oil	Artemisia dracunculus L.	8016-88-4	0,3
Thyme absolute	Thymus vulgaris L.	8007-46-3	0,02
Thyme oil, red	Thymus vulgaris L.	8007-46-3	0,03
Thyme oil, white	Thymus vulgaris L.	8007-46-3	0,03
Tuberose absolute	Poliantes tuberosa L.	8024-05-3	1,8
Tuberose concrete	Poliantes tuberosa L.	8024-05-3	1,8

Annexe I :

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration
1-Octen-3-yl acetate	2442-10-6	0,3
Estragole	140-67-0	0,1
Methyl eugenol	93-15-2	2
Eugenol	97-53-0	51
Eugenol	97-53-0	85,3
Methyl eugenol	93-15-2	1,2
Safrole	94-59-7	1,5
Eugenol	97-53-0	0,2
Isoeugenol	97-54-1	0,5
Geraniol	106-24-1	1,6
Geraniol	106-24-1	1
Citral	5392-40-5	0,5
d,l-Citronellol	106-22-9	0,1
Citronellal	106-23-0	0,4
Geraniol	106-24-1	0,5
Farnesal	19317-11-4	0,2
Citral	5392-40-5	2,8
beta-Thujone	471-15-8	71
alpha-Thujone	546-80-5	0,5
Thujone	76231-76-0; 1125-12-8	71,5
Cedrene	11028-42-5	0,3
alpha-Cedrene	469-61-4	0,2
beta-Cedrene	546-28-1	0,1
Geraniol	106-24-1	0,4
Estragole	140-67-0	0,1
l-Carvone	6485-40-1	0,2
Methyl eugenol	93-15-2	1
Longifolene	475-20-7	0,4
beta-Thujone	471-15-8	0,4
alpha-Thujone	546-80-5	0,1
Thujone	76231-76-0; 1125-12-8	0,5

Restriction type :

RESTRICTION

Cause of restriction :

DERMAL SENSITIZATION

Amendment :

49

Comments :

The natural contribution of Cedrene is determined by the sum of the natural contributions of each of its isomers.

Quantitative limit on the use :

Cat.1	Cat.2	Cat.3	Cat.4	Cat.5A	Cat.5B	Cat.5C	Cat.5D	Cat.6
0,27 %	0,08 %	1,6 %	1,5 %	0,38 %	0,38 %	0,38 %	0,38 %	0,88 %
Cat.7A	Cat.7B	Cat.8	Cat.9	Cat.10A	Cat.10B	Cat.11A	Cat.11B	Cat.12
3,1 %	3,1 %	0,16 %	2,9 %	11 %	11 %	5,8 %	5,8 %	Not restricted

Annexe I :

Some regulated synthetic ingredients are found in nature and in certain proportions in natural ingredients. This presence in nature has to be taken into account when calculating limits of use recommended by the IFRA. In case you do not know these concentrations, you can use the ones estimated by the IFRA. Here They are :

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration
Birch tar oil, rectified	Betula spp.	8001-88-5	0,9
Cade oil, rectified	Juniperus oxycedrus L.	8013-10-3	0,5
Balsam oil, Peru	Myroxylon balsamum (L.) Harms var. pereirae (Royle) Harms	8007-00-9	0,03
Cassia oil	Cinnamomum aromaticum Nees	8007-80-5	0,1
Cinnamon bark extract	Cinnamomum zeylanicum Blume	8015-91-6	0,01
Cinnamon bark oil	Cinnamomum zeylanicum Blume	8015-91-6	0,02
Cinnamon leaf oil	Cinnamomum zeylanicum Blume	8015-91-6	0,13
Jasmine officinale absolute	Jasminum officinale L.	8024-43-9	0,1
Lemongrass oil, East Indian	Cymbopogon flexuosus (Nees ex Steudel) Will. Watson	8007-02-1	0,5
Lemongrass oil, West Indian	Cymbopogon citratus (DC) Stapf.	8007-02-1	0,5
Nutmeg oil	Myristica fragrans Houtt.	8008-45-5	0,5
Tolu, balsam, extract	Myroxylon balsamum (L.) Harms.	8024-03-1	0,08
Tolu, balsam, gum	Myroxylon balsamum (L.) Harms.	8024-03-1	0,02
Tuberose absolute	Poliantes tuberosa L.	8024-05-3	1,5
Tuberose concrete	Poliantes tuberosa L.	8024-05-3	1,5
Ylang ylang oil I	Cananga odorata (Lam.) Hook. f. &Thomson oil (forma genuine Steenis)	8006-81-3	0,5
Ylang ylang oil II	Cananga odorata (Lam.) Hook. f. &Thomson oil (forma genuine Steenis)	8006-81-3	0,5
Ylang ylang oil III	Cananga odorata (Lam.) Hook. f. &Thomson oil (forma genuine Steenis)	8006-81-3	0,5
Ylang, Ylang oil extra	Cananga odorata (Lam.) Hook. f. &Thomson oil (forma genuine Steenis)	8006-81-3	0,5
Ylang, Ylang oil, terpene-free	Cananga odorata (Lam.) Hook. f. &Thomson oil (forma genuine Steenis)	68952-44-3	0,5
Allspice oil	Pimenta officinalis Lindl.	8006-77-7	8,5
Allspice oleoresin	Pimenta officinalis Lindl.	8006-77-7	5,1
Artemisia arborescens extract	Artemisia arborescens L.	92113-09-2	0,07
Basil oil, chemotype estragole	Ocimum basilicum L.	8015-73-4	0,5
Basil oil, chemotype linalool	Ocimum basilicum L.	8015-73-4	0,2
Basil oleoresin, chemotype estragole	Ocimum basilicum L.	8015-73-4	0,2
Bay leaf oil, terpeneless	Pimenta acris Kostel	68916-05-2	2,4
Bay leaf, West Indian, extract	Pimenta acris Kostel	8006-78-8	1,4
Bay leaf, West Indian, oil	Pimenta racemosa (Mill.) J.W. Moore	8006-78-8	2
Calamus oil	Acorus calamus L.	8015-79-0	0,3
Cananga oil	Cananga odorata (Lam.) Hook. f. & Thomson (forma macrophylla Steenis)	68606-83-7	0,2
Cinnamon leaf oil	Cinnamomum zeylanicum Blume	8015-91-6	0,01
Elemi gum	Canarium luzonicum (Blume) A. Gray	8023-89-0	0,07
Elemi oil	Canarium luzonicum (Blume) A. Gray	8023-89-0	0,4
Elemi resinoid	Canarium luzonicum (Blume) A. Gray	8023-89-0	0,07
Hyacinth absolute	Hyacinthus orientalis L.	8023-94-7	1,5
Hyssop oil	Hyssopus officinalis L.	8006-83-5	0,2
Laurel leaf oil	Laurus nobilis L	8007-48-5	3
Mace oil	Myristica fragrans Houtt.	8007-12-3	1,2
Mastic absolute	Pistacia lentiscus L.	68991-39-9	0,01
Mastic oil	Pistacia lentiscus L.	68991-39-9	0,02
Michelia alba extract	Michelia x alba DC. (champaca x montana)	8006-76-6	2,8
Myrtle oil	Myrtus communis L.	8008-46-6	1
Nutmeg oil	Myristica fragrans Houtt.	8008-45-5	1,2
Pimenta leaf oil	Pimenta officinalis Lindl.	8006-77-7	6
Rose absolute	Rosa x damascena Mill.	90106-38-0	0,5
Rose concrete	Rosa x damascena Mill.	90106-38-0	0,5
Rose oil	Rosa x damascena Mill.	8007-01-0	2
Rose water stronger	Rosa x centifolia L.	8007-01-0	0,04
Snakeroot oil	Asarum canadense L.	8016-69-1	40
Tarragon oil	Artemisia dracunculus L.	8016-88-4	0,3
Tea tree oil	Melaleuca alternifolia (Maiden & Betche) Cheel	68647-73-4	0,05
Thyme absolute	Thymus vulgaris L.	8007-46-3	0,02
Thyme oil, red	Thymus vulgaris L.	8007-46-3	0,03
Thyme oil, white	Thymus vulgaris L.	8007-46-3	0,03
Tuberose absolute	Poliantes tuberosa L.	8024-05-3	1,8
Tuberose concrete	Poliantes tuberosa L.	8024-05-3	1,07
Verbena absolute	Lippia citriodora (L.) Kunth	8024-12-2	0,1
Cananga oil	Cananga odorata (Lam.) Hook. f. & Thomson (forma macrophylla Steenis)	68606-83-7	0,4
Cedarwood oil terpenes	Juniperus mexicana Schiede	68608-32-2	18
Cedarwood oil, Atlas	Cedrus atlantica (Endl.) Manetti ex Carriere	8023-85-6	1,5
Cedarwood oil, Chinese	Cupressus funebris Endl.	1159574-01-2	19,1
Cedarwood oil, Texas	Juniperus mexicana Schiede	68990-83-0	12
Cedarwood oil, Virginian	Juniperus virginiana L.	8000-27-9	24,3
Cypress oil	Cupresssus sempervirens L.	8013-86-3	0,4
Helichrysum absolute	Helichrysum angustifolium DC.	8023-95-8	1,8
Helichrysum oil	Helichrysum angustifolium DC.	8023-95-8	0,05
Juniper berry oil	Juniperus communis L.	8002-68-4	0,4
Pine needle, dwarf, oil	Pinus pumila (Pall.) Regel	8000-26-8	0,25
Sandalwood oil, Australian	Santalum spicata (R.Br.) A.DC.	8024-35-9	0,2
Verbena absolute	Lippia citriodora (L.) Kunth	8024-12-2	0,5
Vetiver oil (all origins)	Chrysopogon zizanioides (L.) Roberty	8016-96-4	0,2
Vetiver oil (all origins)	Chrysopogon zizanioides (L.) Roberty	8016-96-4	0,2

To learn more about IFRA's standards : https://ifrafragrance.org/safe-use/library
To find out the specificities of each category and the ingredients prohibited by IFRA, click article about l'IFRA
ScenTree is solely responsible for the information provided here.

Uses in perfumery :

Alpha-Cedrene is generally used for leather notes or as a substitute for Cedarwood Virginia EO, for its substantially equivalent note.

Other names :

(3R-(3a,3ab,7b,8aa))-2,3,4,7,8,8a-hexahydro-3,6,8,8-tetramethyl-1H-3a,7-methanoazulene, (1S,2R,5S)-2,6,6,8- tetramethyl tricyclo(5.3.1.01.5)undec-8-ene

Other comments :

Alpha-Cedrene is a sesquiterpene. This means that it has 15 carbon atoms, linked to 24 hydrogen atoms. In the case of Alpha-Cedrene, the molecule has a tricyclic structure.