ScenTree, la nouvelle encyclopédie des ingrédients de parfum.

Exploring the branches of scent

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Crédits photo: ScenTree SAS

CAS number :

6790-58-5

EINECS number :

229-861-2

FEMA number :

3471

JECFA number :

Data not available.

FLAVIS number :

Data not available.

Volatility :

Base

Appearance :

White solid

Price Range :

€€€€

Stability :

Stable in perfumes and diverse functional bases, except some acid cleaners.

Density :

0.939

Molecular formula :

C₁₆H₂₈O

Molecular Weight :

236.4 g/mol

Flash Point :

321.8°F (161°C)

Log P :

> 6

Fusion Point :

167°F (75°C)

Boiling Point :

318 °C at 1 013 hPa

Detection Threshold :

0.3 ppb (0.00000003% !)

Crédits photo: ScenTree SAS

Year of discovery :

Discovered in 1949.

Synthesis route :

Ambroxan® is a molecule synthesized from laevorotatory Sclareol, obtained from Clary Sage Absolute. The first step in this synthesis is to oxidize Sclareol into a lactone called Sclareolide, in its dextrorotatory form. The second is a hydrogenation of this compound into a diol. The last step is dehydration to obtain Ambroxan® (laevorotatory), the final product. Sclareolide in its racemic form can also be obtained by a purely synthetic route. Therefore, its laevorotatory isomer must be separated before the synthesis of Ambroxan®. Nowaday, there is a better process to obtain Ambrofix. This molecule can be obtained throught a unique multi-step bioconversion process starting from sugar cane. This new process is considered as the most sustainable process for Ambrofix in the market.All carbon atoms of the bio-based starting material are ending up in the product – no Carbon wasted leading to optimal carbon efficiency. Also, it needs 100x less land use to produce 1 kg of the Ambrofix compared to the traditional route based on Clary Sage This new bioconversion route maintains the classification as 100% Naturally Derived. ''

Synthesis precursor :

Ambroxan® is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

The Ambroxan® most often used in perfumery is the laevorotatory isomer of this molecule. Ambrox DL (dextrorotatory and laevorotatory) refers to a racemic mixture of all the isomers of this molecule. The latter, however, is more unstable, as Ambrox tends to return to its laevorotatory form (L). Ambroxan® is a constitutional isomer of Cedramber®, Muscenone® and Sandela®. Cedramber® and Sandela® also have a woody, even ambery note for Cedramber®, but Muscenone® is a pretty different musk.

Natural availability :

Initially, Ambroxan® is present in ambergris which is a whale excretion found dry on beaches. However, it is not extracted. Also, for ethical reasons, ambergris is no longer produced for perfumery. A natural quality of Ambroxan® is used in perfumes : it is called Ambrofix®.

Allergens :

This ingredient does not contain any allergen.

For more information on allergens used in perfumery, please consult our article about allergens

IFRA :

This ingredient is not restricted

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration
Benzaldehyde	100-52-7	0,9
Citral	5392-40-5	0,34
Citronellol	106-22-9	12,2
Eugenol	97-53-0	2,3
Geraniol	106-24-1	5
Methyl eugenol	93-15-2	0,5

Skin contact products	Non skin contact products
Leave on products	Rinse off products

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration
Benzyl alcohol	100-51-6	0,1
Benzaldehyde	100-52-7	1
d,l-Citronellol	106-22-9	6
Geraniol	106-24-1	5
Farnesal	19317-11-4	0,01
Citral	5392-40-5	0,05
Methyl eugenol	93-15-2	0,5
Eugenol	97-53-0	2,3

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration

To learn more about IFRA's standards : https://ifrafragrance.org/safe-use/library
To find out the specificities of each category and the ingredients prohibited by IFRA, click article about l'IFRA
ScenTree is solely responsible for the information provided here.

Uses in perfumery :

Ambroxan® brings an animalic and ambery facet with woody notes. Very good fixator. Replaces ambergris since its discovery, for ethical and price concerns.

Other names :

Ambremor®, Ambrox®, Synambrane®, Cétalox®, Ambrofix®, (3aR,5aS,9aS,9bR)-3a,6,6,9a-tetramethyl-2,4,5,5a,7,8,9,9b-octahydro-1H-benzo[e][1]benzofuran, amber ether, amberxan, ambermox, amberol, ambronica, ambroxene, 8-alpha-12-oxido-13,14,15,16-tetranorlabdane, dodecahydrotetramethyl naphtofuran, lanbroxyde, orcanox, superamber

Other comments :

Ambroxan® is the major ambery note, since ambergris, a natural dejection of an ill spermwhale, is no longer used in fragrances. In the perfume vocabulary, amber notes also refer to amber perfumes, which use cistus notes as Cistus EO and Cistus Labdanum Absolute Green. Ambrofix is the most widely used and most biodegradable ambery molecule.

Cat.1	Cat.2	Cat.3	Cat.4	Cat.5A	Cat.5B	Cat.5C	Cat.5D	Cat.6

Cat.7A	Cat.7B	Cat.8	Cat.9	Cat.10A	Cat.10B	Cat.11A	Cat.11B	Cat.12

Exploring the branches of scent

Year of discovery :

Discovered in 1949.

Synthesis route :

Synthesis precursor :

Ambroxan® is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

Natural availability :

Initially, Ambroxan® is present in ambergris which is a whale excretion found dry on beaches. However, it is not extracted. Also, for ethical reasons, ambergris is no longer produced for perfumery. A natural quality of Ambroxan® is used in perfumes : it is called Ambrofix®.

Allergens :

This ingredient does not contain any allergen.

Annexe I :

Restriction type :

Cause of restriction :

Amendment :

Comments :

Quantitative usage limits :

Annexe I :

Annexe I :

Restriction type :

Cause of restriction :

Amendment :

Comments :

Quantitative limit on the use :

Annexe I :