ScenTree, la nouvelle encyclopédie des ingrédients de parfum.

Exploring the branches of scent

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Crédits photo: ScenTree SAS

CAS number :

1222-05-5

EINECS number :

214-946-9

FEMA number :

Data not available.

JECFA number :

Data not available.

FLAVIS number :

Data not available.

Volatility :

Base

Appearance :

Colorless viscous liquid

Price Range :

€

Stability :

Musks are very stable, as in alcoholic and in functional fragrances

Density :

1.037

Molecular formula :

C₁₈H₂₆O

Molecular Weight :

258.41 g/mol

Flash Point :

>212°F (>100°C)

Log P :

5.92

Fusion Point :

Data not available.

Boiling Point :

579.2°F (304°C)

Detection Threshold :

0.9 ng/L air

Crédits photo: ScenTree SAS

Year of discovery :

Discovered in 1962.

Synthesis route :

Galaxolide® can be synthesized from tert-amylene by reaction with alpha-methylstyrene, to obtain 1,1,2,3,3-pentamethylindane. This intermediate molecule can be hydroxyalkylated by reaction with the propylene oxide, during a Friedel and Craft reaction, catalysed by aluminum chloride, for example. The alcohol function of the second intermediate product obtained during the previous process can be cyclized by reaction with formaldehyde, either in an alcoholic medium or with an acid anhydride, to obtain the final compound, Galaxolide®.

Synthesis precursor :

Galaxolide® is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

Galaxolide® contains several asymmetric carbons that give rise to several enantiomers. Thus, Galaxolide® used in perfumery is actually a mixture of at least seven isomeric molecules with different volatilities. Galaxolide® and Tonalide® are constitutional isomers and have a fairly similar overall structure. Both have a relatively similar smell, as they belong to the same family of musks.

Natural availability :

Galaxolide® is not available in its natural state.

Allergens :

This ingredient does not contain any allergen.

For more information on allergens used in perfumery, please consult our article about allergens

IFRA :

This ingredient is not restricted

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration

Cat.1	Cat.2	Cat.3	Cat.4	Cat.5	Cat.6	Cat.7	Cat.8	Cat.9	Cat.10	Cat.11
0,16 %	0,2 %	0,83 %	2,5 %	1,31 %	3,93 %	0,42 %	2 %	5 %	2,5 %	Not restricted

Skin contact products	Non skin contact products
Leave on products	Rinse off products

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration
Angelica root oil	Angelica archangelica L.	8015-64-3	1,6
Angelica seed oil	Angelica archangelica L.	8015-64-3	0,29
Galbanum gum	Ferula spp.	8023-91-4	0,01
Galbanum oil	Ferula spp.	8023-91-4	0,1
Galbanum resin	Ferula spp.	8023-91-4	0,1

Maximum usage according to the product category :
Ingredients containing
Ingredient Name	CAS N°	Estimated Concentration

Cat.1	Cat.2	Cat.3	Cat.4	Cat.5A	Cat.5B	Cat.5C	Cat.5D	Cat.6
0,42 %	0,13 %	2,5 %	2,4 %	0,6 %	0,6 %	0,6 %	0,2 %	1,4 %
Cat.7A	Cat.7B	Cat.8	Cat.9	Cat.10A	Cat.10B	Cat.11A	Cat.11B	Cat.12
4,8 %	4,8 %	0,2 %	4,6 %	4,6 %	17 %	0,2 %	0,2 %	Not restricted

List of natural ingredients containing the material presented here
Ingredient Name	Botanical Name	CAS N°	Estimated Concentration
Angelica root oil	Angelica archangelica L.	8015-64-3	1,6
Angelica seed oil	Angelica archangelica L.	8015-64-3	0,29
Galbanum gum	Ferula spp.	8023-91-4	0,01
Galbanum oil	Ferula spp.	8023-91-4	0,1
Galbanum resin	Ferula spp.	8023-91-4	0,1

To learn more about IFRA's standards : https://ifrafragrance.org/safe-use/library
To find out the specificities of each category and the ingredients prohibited by IFRA, click article about l'IFRA
ScenTree is solely responsible for the information provided here.

Uses in perfumery :

Galaxolide® gives hold and trail to a perfume. It is one of the freshest and most heady musks. To be combined with other musks to multiply the facets. Widely used in detergents and fabric softeners. Preferential use in laundry. Often used as a replacement for all other musks in the case of a reformulation at a lower cost.

Other names :

Musc 50®, Pearlide®, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-2-benzopyran, astrolide, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethyl cyclopenta-gamma-2-benzopryan, hexahydrohexamethyl cyclopentabenzopyran, musk gx

Other comments :

Often, Galaxolide® is diluted in solvent as it is very viscous : Benzyl Benzoate, Isopropyl Myristate, Triethyl Citrate, Dipropylene Glycol. Like some other polycyclic musk, Galaxolide® is not biodegradable and causes major pollution problems. As a result, some companies have decided to ban this compound from their products.

Exploring the branches of scent

Year of discovery :

Discovered in 1962.

Synthesis route :

Synthesis precursor :

Galaxolide® is not a precursor to the synthesis of another compound of olfactory interest.

Isomerism :

Natural availability :

Galaxolide® is not available in its natural state.

Allergens :

This ingredient does not contain any allergen.

Annexe I :

Restriction type :

RESTRICTION QRA

Cause of restriction :

SENSITIZATION

Amendment :

47

Comments :

Quantitative usage limits :

Annexe I :

Annexe I :

Restriction type :

Cause of restriction :

DERMAL SENSITIZATION AND SYSTEMIC TOXICITY

Amendment :

49

Comments :

Quantitative limit on the use :

Annexe I :